I have a razor naga mouse, so there are 12 buttons on the side to use (although my short thumb can only reach 9 of them). I have them set so 4 is local talk, 5 is primary short range radio, 6 is alt short range, and 9 is primary long range. If you happen to have a naga, this is a pretty effective setup. (Also if you have a naga, recommend you put one of the buttons to be left control. Keeps you from having to contort your hand to hit control and some other key for all of the commands that require the left control button, and doing that while also having to do other stuff can slow you down).